Research

My research goal is to combine each unique and diverse field of study such as biology, chemistry, mechanics, materials, and computational research and create a translational diagnostic platform for rapid and precise detection of disease markers including cancer and infectious diseases.

Research Overview

In vitro molecular diagnostic

of various diseases including respiratory infectious virus (SARS-CoV-2, Influenza) & bloodstream pathogens (bacteria, fungi)

——————————————Ph.D. 4th year projects 1————————————–

  • Point-of-Care Multiplex Detection of Respiratory Viruses (ACS Sensors 2024)
  • Point-of-care diagnostics for respiratory infections
    • SARS-CoV-2, Flu, RSV
    • Simultaneous detection of 4 viruses with two controls
    • Less than 30 minutes
    • Lyophilized reagents
  • Smartphone-based reader
  • Disposable cartridge

——————————————Ph.D. 4th year projects 2————————————–

  • Dried Blood Matrix as a New Material for the Detection of DNA Viruses (Advanced Healthcare Materials 2024)
  • Material characterization
    • BET-BJH analysis
    • FRAP (Fluorescence Recovery After Photobleaching)
    • SEM
    • Immunostaining
  • Virus detection (Hepatitis B Virus)
  • Fibrin structure formation

——————————————Ph.D. 3rd year projects—————————————

  • Inhibitor inactivation mechanism
  • A blood drying process for DNA amplification with its mechanism (Small 2023)
  • Major inhibitors, such as hemoglobin and IgG, are inactivated since they are physically trapped within the dried blood matrix, without being released out
  • Characterization of various condition for better sensitivity biphasic reaction
  • Extension of application to RPA

——————————————Ph.D. 2nd year projects—————————————

  • Detection of bloodstream pathogens
  • Culture-free sensitive detection of pathogens in dried blood (PNAS 2022)
  • Single molecule sensitivity (LOD = 1 cfu/mL) for E.coli, MRSA, MSSA, and C. Albicans within the sample-to-result time <2.5h that bypass the current gold standard blood culture (taking up to 5 days)

——————————————Ph.D. 1st year projects—————————————-

  • Detection of respiratory infectious virus
  • SARS-CoV-2 detection and variants discrimination in a portable detection device using isothermal amplification (Lab on a Chip 2022)
  • First demonstration of the portable system that enables simultaneous detection of SARS-CoV-2 virus and its variant discrimination ability using LAMP

  • Detection of respiratory infectious virus
  • Portable device with crumpled graphene field-effect transistor biosensor (ACS sensors 2021)
  • High sensitivity with low cost and fast detection (< 30 min)
  • Electrical measurement with FET biosensor
  • Crumpled graphene, compared to bare graphene, increased the sensitivity

———————————————Ongoing projects——————————————-